Pym, Alexande: search on Z-Library

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1

Bedaquiline resistance in drug-resistant tuberculosis HIV co-infected patients

Nimmo, Camus, Millard, James, Brien, Kayleen, Moodley, Sashen, van Dorp, Lucy, Lutchminarain, Keeren, Wolf, Allison, Grant, Alison D., Balloux, Francois, Pym, Alexander S., Padayatchi, Nesri, O'Donnel

Journal:

European Respiratory Journal

Year:

2020

File:

PDF, 662 KB

2020

2

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment

Nimmo, Camus, Brien, Kayleen, Millard, James, Grant, Alison D., Padayatchi, Nesri, Pym, Alexander S., O'Donnell, Max, Goldstein, Richard, Breuer, Judith, Balloux, FranÃ§ois

Journal:

Year:

2020

File:

PDF, 1003 KB

2020

3

Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur

Roland Brosch, Stephen V. Gordon, Carmen Buchrieser, Alexander S. Pym, Thierry Garnier, Stewart T. Cole

Journal:

Year:

2000

Language:

english

File:

PDF, 264 KB

english, 2000

4

Regulation of catalase–peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis

Alexander S. Pym, Pilar Domenech, Nadine Honoré, Jian Song, Vojo Deretic, Stewart T. Cole

Journal:

Molecular Microbiology

Year:

2001

Language:

english

File:

PDF, 153 KB

english, 2001

5

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

Alexander S. Pym, Priscille Brodin, Roland Brosch, Michel Huerre, Stewart T. Cole

Journal:

Molecular Microbiology

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

6

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

Pym, Alexander S., Brodin, Priscille, Majlessi, Laleh, Brosch, Roland, Demangel, Caroline, Williams, Ann, Griffiths, Karen E., Marchal, Gilles, Leclerc, Claude, Cole, Stewart T.

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 537 KB

english, 2003

7

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

Diacon, Andreas H., Pym, Alexander, Grobusch, Martin, Patientia, Ramonde, Rustomjee, Roxana, Page-Shipp, Liesl, Pistorius, Christoffel, Krause, Rene, Bogoshi, Mampedi, Churchyard, Gavin

Journal:

Boston Medical and Surgical Journal

Year:

2009

Language:

english

File:

PDF, 410 KB

english, 2009

8

Post DOTS, post genomics: the next century of tuberculosis control

Alexander S Pym, Stewart T Cole

Journal:

Year:

1999

Language:

english

File:

PDF, 70 KB

english, 1999

9

The evolution of mycobacterial pathogenicity: clues from comparative genomics

Roland Brosch, Alexander S. Pym, Stephen V. Gordon, Stewart T. Cole

Journal:

Trends in Microbiology

Year:

2001

Language:

english

File:

PDF, 83 KB

english, 2001

10

Comparative genomics of the mycobacteria

Roland Brosch, Stephen V. Gordon, Alexander Pym, Karin Eiglmeier, Thierry Garnier, Stewart T. Cole

Journal:

International Journal of Medical Microbiology

Year:

2000

Language:

english

File:

PDF, 9.04 MB

english, 2000

11

Announcement

Ngubane, Nqobile A.C., Gresh, Lionel, Pym, Alexander, Rubin, Eric J., Khati, Makobetsa

Journal:

Year:

1988

File:

PDF, 26 KB

1988

12

Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX

Ngubane, Nqobile A.C., Gresh, Lionel, Pym, Alexander, Rubin, Eric J., Khati, Makobetsa

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 780 KB

english, 2014

13

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

Diacon, Andreas H., Pym, Alexander, Grobusch, Martin P., de los Rios, Jorge M., Gotuzzo, Eduardo, Vasilyeva, Irina, Leimane, Vaira, Andries, Koen, Bakare, Nyasha, De Marez, Tine, Haxaire-Theeuwes, Myr

Journal:

New England Journal of Medicine

Year:

2014

Language:

english

File:

PDF, 653 KB

english, 2014

14

The in Vivo Effects of Combination Antiretroviral Drug Therapy on Peripheral Blood CD34+ Cell Colony-Forming Units from HIV Type 1-Infected Patients

Adams, Gregor B., Pym, Alexander S., Poznansky, Mark C., Mcclure, Myra O., Weber, Jonathan N.

Journal:

AIDS Research and Human Retroviruses

Year:

1999

Language:

english

File:

PDF, 238 KB

english, 1999

15

The Rabbit Study: Ritonavir and Saquinavir in Combination in Saquinavir-Experienced and Previously Untreated Patients

Churchill, Duncan R., Pym, Alexander S., Galpin, Sarah, Foxall, Russell, Stainsby, Chris, Clarke, John R., Kaye, Steve, Bloor, Stuart, Larder, Brendan A., Wills, Ben, Sun, Eugene, Babiker, Abdel G., B

Journal:

AIDS Research and Human Retroviruses

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

16

Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

Naiker, Suhashni, Connolly, Cathy, Wiesner, Lubbe, Kellerman, Tracey, Reddy, Tarylee, Harries, Anthony, McIlleron, Helen, Lienhardt, Christian, Pym, Alexander

Journal:

BMC Pharmacology and Toxicology

Year:

2014

Language:

english

File:

PDF, 679 KB

english, 2014

17

A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population

O'Donnell, Max R., Pym, Alexander, Jain, Paras, Munsamy, Vanisha, Wolf, Allison, Karim, Farina, Jacobs, William R., Larsen, Michelle H., Land, G. A.

Journal:

Journal of Clinical Microbiology

Year:

2015

Language:

english

File:

PDF, 582 KB

english, 2015

18

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules

Pan, Shih-Jung, Tapley, Asa, Adamson, John, Little, Tessa, Urbanowski, Michael, Cohen, Keira, Pym, Alexander, Almeida, Deepak, Dorasamy, Afton, Layre, Emilie, Young, David C., Singh, Ravesh, Patel, Vi

Journal:

The Journal of Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

19

Impact of Bacterial Genetics on the Transmission of Isoniazid-Resistant Mycobacterium tuberculosis

Gagneux, Sebastien, Burgos, Marcos V., DeRiemer, Kathryn, Enciso, Antonio, Muñoz, Samira, Hopewell, Phillip C., Small, Peter M., Pym, Alexander S.

Journal:

Year:

2006

Language:

english

File:

PDF, 127 KB

english, 2006

20

Challenges in Estimating the Total Burden of Drug-resistant Tuberculosis

Cohen, Ted, Colijn, Caroline, Wright, Abigail, Zignol, Matteo, Pym, Alexander, Murray, Megan

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2008

Language:

english

File:

PDF, 109 KB

english, 2008

21

The effect of SLCO1B1 polymorphisms on the pharmacokinetics of rifabutin in African HIV-infected patients with tuberculosis

Hennig, Stefanie, Naiker, Suhashni, Reddy, Tarylee, Egan, Deirdre, Kellerman, Tracy, Wiesner, Lubbe, Owen, Andrew, McIlleron, Helen, Pym, Alexander

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 440 KB

english, 2015

22

Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis

Pym, Alexander S., Diacon, Andreas H., Tang, Shen-Jie, Conradie, Francesca, Danilovits, Manfred, Chuchottaworn, Charoen, Vasilyeva, Irina, Andries, Koen, Bakare, Nyasha, De Marez, Tine, Haxaire-Theeuw

Journal:

European Respiratory Journal

Year:

2015

Language:

english

File:

PDF, 399 KB

english, 2015

23

Disease progression and survival in HIV-1-infected Africans in London

Del Amo, Julia, Petruckevitch, Ann, Phillips, Andrew, Johnson, Anne M., Stephenson, Judith, Desmond, Noreen, Hanscheid, Thomas, Low, Nichola, Newell, Anthony, Obasi, Angela, Paine, Katie, Pym, Alexand

Journal:

Year:

1998

Language:

english

File:

PDF, 160 KB

english, 1998

24

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

Cohen, Keira A., El-Hay, Tal, Wyres, Kelly L., Weissbrod, Omer, Munsamy, Vanisha, Yanover, Chen, Aharonov, Ranit, Shaham, Oded, Conway, Thomas C., Goldschmidt, Yaara, Bishai, William R., Pym, Alexande

Journal:

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

25

Dual-Reporter Mycobacteriophages (Φ 2 DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

Jain, Paras, Weinrick, Brian C., Kalivoda, Eric J., Yang, Hui, Munsamy, Vanisha, Vilcheze, Catherine, Weisbrod, Torin R., Larsen, Michelle H., O’Donnell, Max R., Pym, Alexander, Jacobs, William R.

Journal:

Year:

2016

Language:

english

File:

PDF, 3.36 MB

english, 2016

26

Molecular Basis of Drug Resistance in Mycobacterium tuberculosis

Bishai, William R., Cohen, Keira A., Pym, Alexander S.

Journal:

Microbiology Spectrum

Year:

2014

Language:

english

File:

PDF, 307 KB

english, 2014

27

Assessing the utility of Xpert® MTB/RIF as a screening tool for patients admitted to medical wards in South Africa

Heidebrecht, Christine L., Podewils, Laura J., Pym, Alexander S., Cohen, Ted, Mthiyane, Thuli, Wilson, Douglas

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 620 KB

english, 2016

28

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Yadon, Adam N., Maharaj, Kashmeel, Adamson, John H., Lai, Yi-Pin, Sacchettini, James C., Ioerger, Thomas R., Rubin, Eric J., Pym, Alexander S.

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 817 KB

english, 2017

29

Whole transcriptome and genomic analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance

de Welzen, Lynne, Eldholm, Vegard, Maharaj, Kashmeel, Manson, Abigail L., Earl, Ashlee M., Pym, Alexander S.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017

30

Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model

Baijnath, Sooraj, Moodley, Chivonne, Ngcobo, Bongani, Singh, Sanil D., Kruger, Hendrik G., Arvidsson, Per I., Naicker, Tricia, Pym, Alexander, Govender, Thavendran

Journal:

International Journal of Antimicrobial Agents

Year:

2018

Language:

english

File:

PDF, 1.98 MB

english, 2018

31

Evaluation of a synthetic peptide for the detection of anti- Mycobacterium tuberculosis curli pili IgG antibodies in patients with pulmonary tuberculosis

Naidoo, Natasha, Pillay, Balakrishna, Bubb, Martin, Pym, Alexander, Chiliza, Thamsanqa, Naidoo, Kogieleum, Ndung'u, Thumbi, Kasprowicz, Victoria O., Pillay, Manormoney

Journal:

Year:

2018

Language:

english

File:

PDF, 477 KB

english, 2018

32

High-Throughput Sequencing Enhanced Phage Display Identifies Peptides That Bind Mycobacteria

Ngubane, Nqobile A. C., Gresh, Lionel, Ioerger, Thomas R., Sacchettini, James C., Zhang, Yanjia J., Rubin, Eric J., Pym, Alexander, Khati, Makobetsa, Willson, Richard C.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.71 MB

english, 2013

33

International Spread of MDR TB from Tugela Ferry, South Africa

Cooke, Graham, Beaton, R. Kate, Lessells, Richard, John, Laurence, Ashworth, Simon, Kon, Onn, Williams, O. Martin, Supply, P., Moodley, P., Pym, Alexander

Journal:

Emerging Infectious Diseases

Year:

2011

Language:

english

File:

PDF, 148 KB

english, 2011

34

Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture

Nimmo, Camus, Shaw, Liam P., Doyle, Rona, Williams, Rachel, Brien, Kayleen, Burgess, Carrie, Breuer, Judith, Balloux, Francois, Pym, Alexander S.

Journal:

Year:

2019

Language:

english

File:

PDF, 784 KB

english, 2019

35

Correction to: Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture

Nimmo, Camus, Shaw, Liam P., Doyle, Ronan, Williams, Rachel, Brien, Kayleen, Burgess, Carrie, Breuer, Judith, Balloux, Francois, Pym, Alexander S.

Journal:

Year:

2019

Language:

english

File:

PDF, 271 KB

english, 2019

36

Space-time clustering of recently-diagnosed tuberculosis and impact of ART scale-up: Evidence from an HIV hyper-endemic rural South African population

Tomita, Andrew, Smith, Catherine M., Lessells, Richard J., Pym, Alexander, Grant, Alison D., de Oliveira, Tulio, Tanser, Frank

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

37

Lipoarabinomannan point-of-care tests: evaluation with fresh samples needed

Connelly, John T, Grant, Benjamin, Munsamy, Vanisha, Pym, Alexander, Somoskovi, Akos

Journal:

The Lancet Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 41 KB

english, 2019

38

Drug-Resistant Tuberculosis, KwaZulu-Natal, South Africa, 2001–2007

Wallengren, Kristina, Scano, Fabio, Nunn, Paul, Margot, Bruce, Buthelezi, Sandile S.S., Williams, Brian, Pym, Alexander, Samuel, Elisabeth Y., Mirzayev, Fuad, Nkhoma, Wilfred, Mvusi, Lindiwe, Pillay,

Journal:

Emerging Infectious Diseases

Year:

2011

File:

PDF, 298 KB

2011

39

Evidence for expanding the role of streptomycin in the management of drug-resistant M. tuberculosis

Cohen, Keira A., Stott, Katharine E., Munsamy, Vanisha, Manson, Abigail L., Earl, Ashlee M., Pym, Alexander S.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2020

File:

PDF, 1.40 MB

2020

40

Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis

Nimmo, Camus, Millard, James, van Dorp, Lucy, Brien, Kayleen, Moodley, Sashen, Wolf, Allison, Grant, Alison D, Padayatchi, Nesri, Pym, Alexander S, Balloux, FranÃ§ois, O'Donnell, Max

Journal:

The Lancet Microbe

Year:

2020

File:

PDF, 493 KB

2020

41

Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection

Ndlovu, Lerato N., Peetluk, Lauren, Moodley, Sashen, Nhamoyebonde, Shepherd, Ngoepe, Abigail T., Mazibuko, Matilda, Khan, Khadija, Karim, Farina, Pym, Alexander S., Maruri, Fernanda, Moosa, Mahomed-Yu

Journal:

Frontiers in Immunology

Year:

2020

File:

PDF, 1.10 MB

2020

42

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D96. WHAT'S NEW IN TUBERCULOSIS DIAGNOSTICS - Diagnosis Of Tuberculosis (TB) In A High HIV Prevalence Setting - Evaluation Of Programmatic Practices And Implications For New Diagnostic Technologies In South Africa

Bronner, Liza E., Podewils, Laura J., Bristow, Claire, Bantubani, Nonkqubela, Pym, Alexander, Mametja, David

Year:

2012

File:

PDF, 26 KB

2012

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